By Kursad Turksen (eds.)
Adult Stem Cells, moment version, takes a serious examine concerns about the developmental or differentiation strength for quite a few tissue kinds and for particular grownup stem telephone kinds. because the first variation seemed a decade in the past, our figuring out of grownup stem cells, and extra particularly tissue-specific grownup stem cells, has complicated drastically. And an elevated curiosity in regenerative medication and capability stem mobilephone functions has pushed a quest for larger figuring out of stem phone biology. In flip, this has spawned a lot task on new release and usage of extra and higher reagents to spot and isolate stem cells and stem cell-like subpopulations, and on assays elucidating their developmental or differentiation power and practical integration with host tissues and organs.
In this absolutely up to date new version, chapters disguise subject matters starting from signaling pathways protecting stemness in hematopoietic cells to regeneration after harm and endocrine mechanisms underlying the stem telephone idea of getting older. different chapters conceal stem cells through organ or process together with pituitary, cardiac, epithelial, tooth, lung, ovary, prostate, liver, and plenty of extra. Importantly, the authors of the chapters haven't purely summarized their successes, yet have additionally summarized many of the problems that every specific box continues to be dealing with with appreciate to maximizing the software of stem cells in scientific settings. jointly, they communicate either the thrill and demanding situations dealing with stem mobilephone usage for fix and regeneration making this ebook crucial studying for these occupied with stem mobilephone study in addition to these occupied with medical assays.
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Extra resources for Adult Stem Cells
Hsu YC, Fuchs E (2012) A family business: stem cell progeny join the niche to regulate homeostasis. Nat Rev Mol Cell Biol 13(2):103–114 60. Niemeyer CM, Sieff CA, Mathey-Prevot B, Wimperis JZ, Bierer BE, Clark SC, Nathan DG (1989) Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines. Blood 73(4):945–951 61. McSweeney PA, Niederwieser D, Shizuru JA, Sandmaier BM, Molina AJ, Maloney DG, Chauncey TR, Gooley TA, Hegenbart U, Nash RA, Radich J, Wagner JL, Minor S, Appelbaum FR, Bensinger WI, Bryant E, Flowers ME, Georges GE, Grumet FC, Kiem HP, Torok-Storb B, Yu C, Blume KG, Storb RF (2001) Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects.
These cultures are also commonly referred to as marrow stromal cell (MSC) cultures but are The Adult Stem Cell Niche 19 Fig. 2 Panel a: Schematic representation of Dexter long-term culture (LTC). A complex adherent layer of various stromal elements forms and supports the production of hematopoietic cells. As hematopoietic cells mature, they are released from the adherent layer into the media. Panel b depicts a phase-contrast photomicrograph of a typical human LTC showing its complexity. Panel c depicts a cobblestone forming area where progenitors crawl under the stromal layer and appear less refractile, and maturing forms are released from the layer and appear phase bright still heterogeneous.
The other “endothelial niche” model proposes that HSCs localize close to endothelial cells that line marrow sinusoids. Evidence for the Fig. 3 Schematic representing the major cellular interactions in the stem cell niche The Adult Stem Cell Niche 21 “endothelial niche” comes from experiments where cells expressing the SLAM family of surface receptors, which are highly expressed in HSCs, were detected in close association with vascular endothelium . However, there are conflicting data that do not support either of the two proposed model systems.
Adult Stem Cells by Kursad Turksen (eds.)